Automobiles are available in a variety of colors. very dangerous for their occupants—over 1 million people globally die in car accidents every year. An additional 20-50 million are also affected by non-fatal accidents each year. These are terrible statistics. 

But driving doesn’t have to be this way. Many people hope that self-driving cars in the future will reduce the amount of car accidents each year. However, auto manufacturers want to make progress sooner. In reality, car safety may be addressed by 2023.

Carmakers including Mazda and Toyota are building a new generation of automobiles fitted with an array of sensors—from ECG sensors mounted on your steering wheel to ear-set sensors that can detect when drivers are not fit to drive. These sensors can detect sudden illnesses such as a heart attack or epileptic seizure, and even drunk driving. Human error accounts for over 90 percent of all auto accidents, and the introduction of multi-modal sensors (like the optical sensors and physiological monitors mentioned) to cars will continue to reduce risks for drivers and others on the road.

The most important thing is that this car will keep you safe and healthy as you drive it in 2023.

In 2023, we will continue to see a growing intersection between wellness, mobility, and AI—specifically, the evolution of multi-modal sensors to track and positively influence drivers’ health and wellness (physical, emotional, and mental). Consider Audi’s “Urbansphere” concept, which was unveiled earlier this year. It will feature stress-detection software that uses technologies such as facial scanners, voice analysis monitoring systems and AI to determine how drivers feel at any moment. The real-time data can then be used to provide personalized relaxation suggestions to drivers. This could include guided meditation.

Similar technologies are being used in the automotive industry by companies like Hyundai. The company’s “Smart Cabin” is equipped with sensors that can record a driver’s vital signs and adjust car conditions based on data collected. If the CO is detected, it can adjust car conditions based on that data.₂ If your car is registering dangerous levels, you can have your car roll down the windows and activate your outside circulation mode. This is an ongoing acceleration of programs developed by companies including Mercedes, where in-car comforts like the Energizing Coach suggest appropriate wellness interventions based on a driver’s monitored stress levels.

With car sales sitting at over 65 millions vehicles globally this year, there’s plenty of data-backed opportunities to keep us both safe and healthy on the road.

Responsible drivers take care of their vehicles. Tune-ups and regular maintenance are important to protect our investment. But in 2023, we’ll see our vehicles taking care of us too. The automotive industry is booming with multi-modal AI technologies, self-care being a top priority, and money flooding in. Your car can become an oasis of well-being.

WIRED reported that 12 It was months before we knew that 2022 would prove to be the year of electric cars. We were correct judging by the 18 models that we recommended you watch for and the long waiting lists for electric cars. 

These wait times aside, there was a steady trend towards increasing EV sales and decreasing internal combustion engine car sales. The US saw a 49% increase in electric vehicles sold during the first half 2022. China saw a staggering 113 percent increase in electric car sales. Full EVs accounted to 13 percent in global new vehicle sales last year. International Energy Agency projects that electric cars will make up more than half of all new vehicles by 2010. 

Combining this consumer demand with the newer battery technology, you can see that the popularity of electric cars is moving in the right direction. 

The best rides will be tested, from $5K Chinese minis to German super saloons. Maybe our editor-in-chief will even review more electric motorcycles. Here’s our selection of the top electric cars WIRED believes will be available in 2023. 

DeLorean Alpha5

DeLorean Alpha5

Photo by DeLorean

Followers of Back to the Future should be sitting down as we tell you that this is DeLorean’s first car in more than 40 years. This car is not powered by gasoline, but it can be fully electric. It will accelerate from 0-60 mph to 60 in less than three seconds. Next, it will reach its maximum speed of projected 155 mph. The Alpha5 is a remake of its movie-star predecessor with a louvered back window and gullwing doors. However, the DMC-12’s blocky, wedge shape has been ditched in favor of a smoother styling that reduces drag enough to help it achieve the 300-mile range DeLorean claims. Cambridge Audio’s high-end stereo experts have been brought in for this purpose. Love is the power of Love sounds superb. Delivery to lucky customer is planned for 2023. What? Really? Ok, now it’s time to get from zero to about 88 mph in 4.35 seconds. Bravo Scott 

Kia E9

Revealed at the 2021 Los Angeles Auto Show and expected to hit UK showrooms in 2023, Kia’s EV9 SUV looks to continue the transformation of the brand from ICE also-ran to a leading EV player. It features a solar panel embedded in the bonnet of the vehicle and an interior that is made with sustainable materials. Then there’s the “pop-up” steering wheel, a 27-inch ultrawide display, panoramic sunroof, and three rows of seats. With its rugged design, the EV9 is poised to challenge Range Rover’s all-terrain car. It will run on the Kia group’s superb Electric Global Modular Platform (E-GMP), the same used in the EV6, which means top-drawer 800-volt electrical architecture and lightning-quick charging at rates of up to 350 kW. Lastly, the EV9 will be the first Kia to offer Automode, the company’s autonomous driving tech.

BMW iX1

Yes, the luxurious i7 will be the EV poster child for BMW in 2023, but it’s the iX1 that will be more important in the coming year for the brand. Why? It replaces the iconic and sorely missed i3 as BMW’s entry-level EV. Customer deliveries will commence in early 2023, with pricing from £52,255 in the UK and $82,900 in the US, and the xDrive30 dual-motor version should offer an output of 313 hp and a WLTP driving range of up to 272 miles from the 64.7-kWh battery. It is possible to charge the battery at up 130 kW in as little as 29 minutes or to extend its range by 75 miles. What’s the clincher? This new X1 is a cleverly designed vehicle that transforms from a toy car into a rugged, reliable runabout.

Audi A6 E-Tron

Audi A6 E-Tron

Photo: Audi

The fully-electric A6 model has been awaited for a while. Audi presented the concept at the Shanghai motorshow in 2021. Positioned firmly as a rival to the coming BMW i5 and Tesla’s Model 3 and Model S, the Audi A6 E-Tron will be based on the group’s latest PPE (Premium Platform Electric) EV architecture, which will also be used on the next Porsche Macan EV and Audi Q6 E-Tron. The greatest advantage of the new platform will be that owners can enjoy fast 800-volt charging as well as longer range due to its 100-kWh capacity. The range could reach 400 miles. Audi may continue to be obsessed with door cameras, if you are crazy enough to go for that option. But projection headlights will still win the race. The Avant estate and 600-bhp RS6 E-Tron will also be available.

Tesla Cybertruck

Tesla Cybertruck

Tesla, Photograph

Elon Musk promises that the Tesla Sci-Fi pickup will finally be available to customers by the end of 2023, regardless of whether you’re a huge fan or just think it looks strange. It’s happened before. Other Tesla models have experienced delays. But this time Tesla says it’s going to happen … it will arrive … pinky promise … even if the Cybertruck’s production is Jahre Later than initially planned. The Austin, Texas, Gigafactory has supposedly been readied for “early production,” and the plan apparently is to gradually ramp up output to full by the end of 2023. The pickup was $100 and hundreds of thousands of people who bought it will keep their fingers crossed that Musk delivers the promised performance. It has a 14,000-pound towing weight, an acceleration of 0-60 seconds, and can travel 500 miles. They will be watching the price closely. Musk claimed that the pickup would be priced below $40,000 but, surprisingly, those prices are now gone from the website.

Lucid Air Sapphire

Lucid Air Sapphire

Lucid Motors

I’ve seen the Lucid Air Sapphire up close—I’ve even sat in it—and I’m happy to tell you that it’s got much more character than the aerodynamically friendly jelly-mold design would suggest. It is a four-door, large EV with high performance. Three of Lucid’s mightily impressive, comparatively slender motors (instead of the standard Air’s two) will result in this Sapphire version outputting more than 1,200 bhp. Maybe quite a bit more. Even though it weighs in at 2.5 tonnes, the EV can accelerate from standstill to 60 mph in under two seconds and then to 100 mph within four. According to the rumors, it will reach quarter-mile in nine seconds. It is close to Rimac Nevera territory. The hypercar cost $2.1 million. Sapphire costs $249,000 with carbon-ceramic brakes, stiffer suspension and custom Michelin Pilot Sport 4S rubber. You’ll also find seats at the back.

Ford ‘Medium-Size Crossover’

Ford’s 2023 “Medium-Size Crossover” EV

Ford Photograph

At the time this article was written, very little information about Ford’s new EV is available. Why do we add it? It’s a beautiful piece of art that we have seen in person and will surely be a hit in Europe. We can safely say it borrows design elements from the Ford Explorer. Others might describe it as an SUV-sized Mini-Me. The “Medium-Size Crossover,” part of the raft of vehicles Ford announced back in March, is going to be the kind of car that those waiting for Range Rover to pull its finger out and just get the hell on with making a full EV Evoque may well jump ship for. Even though the EV Evoque is coming in 2024, Discovery Sport and the EV Evoque are still a ways off. Ford’s Cologne plant will produce the Ford EV.

Hyundai Ioniq 6

Hyundai Ioniq 6

Photo:

WIRED has always been a big fan of Hyundai and Kia’s work in the past. The latest offering coming in “early 2023” is this, the sleek and sporty Ioniq 6. Because it gives them greater range, EVs love being aerodynamic. The Ioniq 6’s efficient profile—pleasingly with more than a whiff of Porsche 911 about it, albeit with four doors—results in a low drag coefficient of 0.21, making it one of the world’s most aerodynamic cars. Hyundai has managed to get up to 338 miles from its long-range lithium-ion battery pack with the single-motor, rear-wheel-drive variant. With two integrated electric motors at the rear and front axles, this all-wheel-drive version delivers 239kW power in a time of just 5.1 seconds. The group’s 800-volt fast charging system is standard, however, it may be better to skip optional digital side mirrors if the vehicle you intend on purchasing.

Fisker Ocean

Fisker Ocean

Photo by Fisker Inc.

Fisker Ocean takes the award for best-looking electric SUVs, coming in 2023. If you’re a keen observer, the Ocean was the winner of our last-year selection. It has been delayed since then, making it difficult to choose the vehicle again. However, our love for this EV doesn’t seem to have diminished over the wait. When enabled on the 17.1-inch screen, the Hollywood Mode rotates it from landscape to portrait so that occupants can enjoy streaming movies. The battery has a range up to 391 mile. It takes less than 3 seconds to go from 0-60. Don’t overlook the SolarSky roof that extends to full sun exposure. It can purportedly emit as much as 1,500 methanol-emissions to drivers.free One hundred and fifty miles per annum. Bidirectional charging allows you to charge your whole home up to 7 days. It can also boost other EVs. Finally, California Mode sees at the push of a button all eight glass panels (including the “Doggie Windows”) open simultaneously to transform the SUV into a “convertible.”

Toyota Prius 2023

Toyota Prius 2023

Toyota

What about a sleek, shiny new Prius? This one looks really cool. Auto world nearly exploded at the announcement. While previous Priuses—Pri-i?—have long been seen as dowdy, and justifiably so with their nondescript shape and normcore vibe, this 2023 iteration looks positively sleek by comparison. But, until you see the car in person, our final verdict will be withheld. The car could be improving upon a flawed design. The car isn’t an electric vehicle, it is a combination of a gasoline-electric engine and a combustion-electric one. Toyota’s new Prius claims to get 57mpg. Solar panels allow for the charging of the battery when the car is not in motion. Other new features include a hands-free Driving mode

Mini Aceman

Mini Aceman

Photo: Mini

Although the Mini Aceman Concept was announced last year, it will not be the final version until 2023. Unfortunately, we will have to wait until 2024 before we can test the car. This is why the Aceman is on the list to reveal the design. It is because this rugged and urban crossover SUV is quite a departure from Mini’s previous designs. And we hope they stick with this version. This may well happen, too, as Mini says this concept is “80 percent true” to the final production design. “This concept is previewing everything that will come after it. Whatever model follows will take a few leaves out of this new book of design,” Adrian van Hooydonk, BMW Group’s design director, told us at the launch. Even though it’s just over 13 feet in length and just under 6 feet wide, the Aceman will fit between Cooper and Countryman models. It will run on the same platform as that of the coming “classic” three-door Mini, set to hit roads next year, also with a complete design refresh. We expect the Aceman to be able to travel less than 300 miles. But, we hope for much more. 

Jeep Avenger

Jeep Avenger

Photo by Jeep

The best small SUVs, particularly if they can be fully electric, are the ones to buy. Jeep, just like Ford, has its sights on European dominance with the new Avenger. It will be available for purchase in 2023. Some might say with 150 bhp and front-wheel drive this is not a very Jeep Jeep—a four-wheel-drive version is coming, though. It is actually the sister vehicle of Vauxhall Mokka and Peugeot 2008, and will be made in Poland. Stellantis’s CMP platform produces up to 154 bhp and 260 Newton-meters of torque in the single-motor version, while the 54-kWh battery with rapid charging at 100 kW should be good enough to take the pack from 20 to 80 percent in just 24 minutes. Range? Distance: 249 mi (or 342 in stop-start traffic).

VW ID.7 (Aero B)

VW’s ID. Vizzion concept car

Photograph: INGO BARENSCHEE/Volkswagen

Pay attention! The VW ID.7 four door will soon be available as a production model. Aero, which is also a concept car that has been in production since the ID’s creation. Vizzion concept car. We are still here. Good. Good. A variety of single-motor RWD and dual motor AWD models are available, as is a GTX variant. It can reach zero to 62 MPH in only 5.6 seconds. A single-motor motor can go from 0 to 62 in 8.5 seconds. A 10-minute charge will add about 143 miles to the 200 kW engine. There is also talk of bidirectional charging for the ID.7. 

Xpeng G9

Xpeng G9

Photo by Xpeng Motors

Only a few months ago did Chinese brand Xpeng reveal its G9 “smart SUV,” the fourth car in the emerging brand’s lineup. After the G3i SUV and G5 saloons, the new model is the fourth in Xpeng’s lineup. G9 is the new brand’s flagship and will include all of the latest tech. RWD Standard Range models are 308 bhp with 430 Nm of torque and deliver zero-to-60 mph speeds of just 6.4 seconds. It claims a range of 354 miles. The RWD Long Range model, though, increases the G9’s range to a respectable supposed 436 miles. The selection includes the following all-wheel-drive models: 650X Performance, 650X Power, and 650X Launch Edition. Each car boasts 543 bhp, 717 Nm, and an claimed time to zero-to-62 of only 3.9 seconds. It also has 403 miles of range. All cars are equipped with lidar to provide driver assistance as well street-level routefinding. Supported charging rates up to 480kW mean that you can add as many as 124 miles in five minutes and a 10- to 80 percent charge in as little as 15 minutes. If true, this would make the G9 the world’s fastest-charging electric SUV. For music lovers, a “5D multimedia system” called Xopera is available with 28 speakers and an output of 2,250 watts.

Polestar 3

Polestar 3

Photograph: Stefan Isaksson/Polestar

The Polestar 3 can be ordered now but production will not begin until summer 2023. You get the slick Scando design, of course, which helps belie the car’s considerable size: 4.9 meters long, 2.1 meters wide—yet it still somehow manages to look sporty. The car’s impressively low drag factor (just 0.29) may be a help. A 14,5 inch touchscreen displays the Google Operating System (which is still a huge plus for Polestar Volvo), and five radar modules and five external cameras provide driver monitoring and safety. You can spec a 25-speaker Bowers & Wilkins surround-sound audio system, which will be useful as the 111-kWh battery will carry you up to 379 miles, so you’ll be spending a lot of time in the car. It won’t take long to charge up the car, as it takes only 30 minutes to top up at 10 to 8 percent. Want speed? You want speed? The Performance Pack increases power by 510 HP, torque to 910Nm and zero to 62 MPH in just 4.7 seconds. It can also accelerate to 130 MPH. You can also get the EX90 Volvo with seven seats built on the exact same platform. It will not be released until 2024.

Lotus Eletre

Lotus Letre

Lotus photograph

As we pointed out earlier in 2022, Lotus’s good-looking all-electric SUV has a grill that “breathes” thanks to interconnected triangular panels at the front which close when the Eletre is stopped (or when it needs to reduce aerodynamic drag) but automatically open to scoop air to the radiator to cool the electric motors, battery pack, or front brakes when needed. During the cars locking and unlocking sequence, this active grill “breathes” as the illuminated flush-fitting door handles deploy, opening and closing the vented panels. Fancy. Fancy. The Lotus will be able to reach a range of 248 miles in as little as 20 minutes with 350kW charging. You can find the full article at The Standard KEF sound system is a 1,380-Watt, 15-speaker affair, while you can upgrade to the 2,160-Watt, 23-speaker “Reference” version if you have spare ears. One note for prospective buyers. Lotus has been pushing back on the Evija numerous times. We are crossing our fingers that 2023 will be available.

Rolls-Royce Spectre

Photo by Rolls-Royce Motor Cars

Rolls-Royce is an unlikely candidate to convert to electric vehicles. But, it’s a subsidiary owned by the BMW Group and has been since 2003. Given that BMW embraces electric vehicles, Rolls-Royce’s first ever electric vehicle was the Spectre. The Spectre is an EV-designed vehicle. This is what’s most pleasing. A new aluminum chassis has been designed to provide the quiet, yet powerful rides that owners of other brand cars can expect. A car that is nearly 5.5 meters in length and almost three tons weighs just over 3 tons has an expected 300+ miles range. It also boasts a 4.4 second zero-to-60 speed. As you can see, EVs need to cut through the air efficiently. This is why the Spectre, a car that is nearly 5.5 meters long and almost 3 tons, is so aerodynamic.

In 2020, during Concerns about food supply and quality were very high during the Covid-19 crisis. This prompted big changes to the way some food is produced: There was a rise in the use of regenerative farming principles—methods of growing food that also support nature by, for instance, keeping soils healthy and stable, improving water and air quality, and improving local biodiversity—and an expansion of food production in and close to cities, leading to less waste. 

In 2021, PepsiCo, Danone, Nestlé, and Unilever—vast, multinational, fast-moving consumer goods (FMCG) companies—announced they were adopting regenerative agricultural practices across millions of acres of farmland. This has been complemented by growth in urban farming, with vertical farming business Infarm recently opening the largest urban farm in Europe, covering 10,000 square meters. These developments are important steps towards a more resilient system of food that benefits both humans and nature. 

We know today that food systems must be resilient to unexpected shocks like the pandemic. In 2023, we will be redesigning food to also help us solve pressing global challenges including climate change and biodiversity loss.

This is possible only if the entire system can be designed to be regenerative. Instead of bending nature in order to make food, the food system must be designed to allow nature to flourish. FMCGs as well as retailers and innovators in 2023 will assume this responsibility, working together with farmers to establish a circular economic system for food. 

They will start to choose ingredients that aren’t only regeneratively produced but are also lower-impact, diverse, and upcycled. You don’t have to make breakfast cereals with wheat from conventional farming. Instead, use a mix of peas and wheat. According to a recent study, making cheese, cereal, and potato products using this approach could reduce greenhouse gas emissions from the food industry by 70 percent and reduce its impact on biodiversity loss by 50 percent in Europe. It is significant because the global food system accounts for one third of all greenhouse gas emissions.

We’re already seeing seeds of change that will grow in 2023. Brazilian coffee producer Guima Café, supported by Nespresso and reNature, is becoming a regenerative coffee farm, producing more types of ingredients from the same land and diversifying its offering. Products that are made with upcycled ingredients are appearing on supermarket shelves, including Renewal Mill’s Dark Chocolate Brownie Mix and Seven Bro7hers’ Sling It Out Stout, brewed using upcycled Kellogg’s Coco Pops. British food brand Hodmedod wants to find lesser-known and less impactful foods, such as black badgerpeas or fava beans.

It is not only policymakers who are taking actions. New government schemes in the UK reward farmers and land mangers for their services, such as providing clean water to wildlife and plants. It allows them to thrive, and helps reduce climate change. There are pilots already in operation and more UK land managers will participate in 2023.

The list is just the beginning. In 2023, we will see the launch of an innovation challenge—supported by the People’s Postcode Lottery—aimed at FMCGs, retailers, and food innovators to bring more iconic food products made with lower-impact, diverse, upcycled, and regeneratively produced ingredients to market. These products will demonstrate the benefits of circular design in food production. 2023 is the year that whole food products will be redeveloped to support nature’s growth.

In times of economic decline, businesses resort to muscle memory and do what they’ve done before. That often means budget cuts—and the deepest cuts commonly target technology investment and people.

However, this time things feel drastically different. More businesses see tech talent as a strategic investment they’ve worked hard for, and are wary of losing it.

New McKinsey & Company research discovered that 55 percent of 1,100 companies surveyed globally have found it challenging to hire key data and tech roles, such as data and software engineers, data architects, machine learning engineers, and data scientists. And a majority said it’s only getting harder, despite offering even more attractive compensation packages and flexible work models.

The real question for CEOs should not be how to Technology costs can be cut but how to Keep and inspire their top tech talent. Simply put: What can you do to make them happy?

Speaking to McKinsey, the tech investor Marc Andreessen said businesses should “find the smartest technologist in the company and make them CEO.” 

That doesn’t mean CEOs that can’t code are out of a job—most business leaders have never been a data scientist or software engineer—but they need to learn to be real advocates and enablers of this finite group of the best technologists. 

Happier tech talent will be drawn to companies where they are treated as entrepreneurs and not just order-takers, beyond the foosball tables and coffee shops of the 2000s. 

IT departments no longer have to be concerned with managing vendor relationships and gathering requirements. They are now shifting away from an output-oriented culture and embracing outcomes as the key to success. A result-focused culture empowers tech talent and allows them to address real issues with quantifiable, high-impact results. 

A business’s digital products can drive growth, and they are also able to deliver inclusive and sustainable growth. Projects have definite budgets and schedules that can be easily discarded when things become difficult. You can’t build a successful product in a project management environment; tech talent burdened with that bureaucracy who feel they don’t have a seat at the business table will soon head toward the exit.

If tech-talent happiness starts and ends with having a product culture, what if, in 2023, more CEOs were to think of themselves as chief product managers leading an outcome culture, in the same way that product managers think of themselves as “mini-CEOs”? The result would be a system that allows small teams to work together in a cross-functional environment. This will make it possible for brilliant, happy people from all walks of the organization. engineers and designers with a clear mission to work on knotty problems with measurable outcomes that matter to—but are not suffocated by—the business or its processes. This means that they should be able to focus on what is important. 

Your tech talent is more valuable than ever. And a product culture is not just for tech companies; it’s also how more traditional companies start behaving like tech companies to compete. Almost all the big problems facing businesses today—whether it’s supply chain dislocation, stimulating customer demand, geopolitical tensions, or payment collection—will have technology-led answers. The best tech talent can be positioned correctly so that the most effective solutions are often found from the bottom up and not the top. It will often be an engineer—with knowledge of the latest technologies and what’s actually feasible—who finds the way forward.

This culture is essential if the business wants to retain employees, move quickly, make value and remain resilient in the face the many headwinds.

Technology talent needs clear goals and quick feedback loops in order to determine if they’re hitting their mark. In return, the best businesses in 2023 will make tech talent “happiness” a primary measure of success. 

The life expectancy is Since the 1800s, the number of countries that perform best has increased by 3 months each year. Throughout most of human history, you had a roughly 50–50 chance of making it into your twenties, mainly due to deaths from infectious diseases and accidents. Thanks to medical advances, we’ve gradually found ways to avoid and treat such causes of death; the end result is perhaps humanity’s greatest ever achievement—we’ve literally doubled what it means to be human, increasing lifespans from 40 to 80 years. On the other hand, this has allowed one scourge to rise above all the others to become the world’s largest cause of death: aging.

Aging is now responsible for over two-thirds of deaths globally—more than 100,000 people every day. This is because, counterintuitive though it may sound, the chief risk factor for most of the modern world’s leading killers is the aging process itself: Cancer, heart disease, dementia, and many more health problems become radically more common as we get older. Although smoking and poor nutrition can all increase your risk for chronic diseases such as heart disease, diabetes, or other serious illnesses, these factors are minor in comparison to the effects of aging. High blood pressure increases the risk of having heart attacks by twofold, while being older than 40 makes your risk increase by ten. The number of deaths and suffering that aging causes will increase as the world population age.

But this isn’t my prediction—apart from being depressing, extrapolating a two-century trend for a further year is hardly groundbreaking. What’s far more exciting is that, in 2023, we may see the first drug that targets the biology of aging itself.

Scientists now have a good handle on what causes us to age, biologically speaking: The so-called “hallmarks” of the aging process range from damage to our DNA—the instruction manual within each of our cells—to proteins that misbehave because of alterations to their chemical structure. The best part is that we have now ideas about how to Treat them.

By the end of 2023, it’s likely that one of these ideas will be shown to work in humans. One strong contender is “senolytics,” a class of treatments that targets aged cells—which biologists call senescent cells—that accumulate in our bodies as we age. These cells seem to drive the aging process—from causing cancers to neurodegeneration—and, conversely, removing them seems to slow it down, and perhaps even reverse it.

In 2018, a 2018 study showed that mice treated with senolytic cocktails of quercetin and dasatinib, a cancer drug, not only lived longer but were also less likely to develop diseases such as cancer. They could even run faster and farther on tiny treadmills designed for mice.

Over two dozen companies are searching for ways to safely and effectively eliminate these senescent human cells. Unity Biotechnology is the largest company. It was founded by Mayo Clinic scientists and investors, including Jeff Bezos. They are currently testing a variety of senolytic medications against lung diseases such as macular degeneration, which can cause blindness, and lung fibrosis. There are many approaches under investigation, including small proteins that target senescent cells, vaccines to encourage the immune system to clear them out, and even gene therapy by a company called Oisín Biotechnologies, named after an Irish mythological character who travels to Tir na nÓg, the land of eternal youth.

Senolytics aren’t the only contenders, either: Others currently in human trials include Proclara Biosciences’ protein GAIM, which clears up sticky “amyloid” proteins, or Verve Therapeutics’ gene therapy to reduce cholesterol by modifying a gene called PCSK9. It is likely that the first anti-aging drug will target an individual age-related condition, not aging in general. We will soon be able to look at this goal if we see a drug which targets an aspect of aging through clinical trials.

These treatments may be the catalyst for the biggest medical revolution since the invention of antibiotics in 2023. Rather than going to the doctor when we’re sick and picking off age-related problems like cancer and dementia in their late stages when they’re very hard to fix, we’ll intervene preventively to stop people getting ill in the first place—and, if those treadmill-shredding mice are anything to go by, we’ll reduce frailty and other problems that don’t always elicit a medical diagnosis at the same time.